Moura Duarte, Mano João F, Paiva Maria C, Alves Natália M
3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal; Institute for Polymers and Composites/I3 N, Department of Polymer Engineering, University of Minho, Guimarães, Portugal.
3B's Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal; ICVS/3B's, Associate PT Government Laboratory, Braga, Guimarães, Portugal.
Sci Technol Adv Mater. 2016 Oct 10;17(1):626-643. doi: 10.1080/14686996.2016.1229104. eCollection 2016.
Chitosan (CHI), a biocompatible and biodegradable polysaccharide with the ability to provide a non-protein matrix for tissue growth, is considered to be an ideal material in the biomedical field. However, the lack of good mechanical properties limits its applications. In order to overcome this drawback, CHI has been combined with different polymers and fillers, leading to a variety of chitosan-based nanocomposites. The extensive research on CHI nanocomposites as well as their main biomedical applications are reviewed in this paper. An overview of the different fillers and assembly techniques available to produce CHI nanocomposites is presented. Finally, the properties of such nanocomposites are discussed with particular focus on bone regeneration, drug delivery, wound healing and biosensing applications.
壳聚糖（CHI）是一种具有生物相容性和可生物降解性的多糖，能够为组织生长提供非蛋白质基质，被认为是生物医学领域的理想材料。然而，其缺乏良好的机械性能限制了它的应用。为了克服这一缺点，壳聚糖已与不同的聚合物和填料相结合，从而产生了多种基于壳聚糖的纳米复合材料。本文综述了对壳聚糖纳米复合材料及其主要生物医学应用的广泛研究。介绍了用于制备壳聚糖纳米复合材料的不同填料和组装技术的概述。最后，讨论了此类纳米复合材料的性能，特别关注骨再生、药物递送、伤口愈合和生物传感应用。
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