Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Top Curr Chem (Cham). 2022 Feb 12;380(2):13. doi: 10.1007/s41061-022-00364-y.
Captivating achievements in developing advanced hybrid biostructures through integrating natural biopolymers with inorganic materials (e.g., metals and metalloids) have paved the way towards the application of bioactive organometallic scaffolds (OMSs) in tissue engineering and regenerative medicine (TERM). Of various biopolymers, chitosan (CS) has been used widely for the development of bioactive OMSs, in large part due to its unique characteristics (e.g., biocompatibility, biodegradability, surface chemistry, and functionalization potential). In integration with inorganic elements, CS has been used to engineer advanced biomimetic matrices to accommodate both embedded cells and drug molecules and serve as scaffolds in TERM. The use of the CS-based OMSs is envisioned to provide a new pragmatic potential in TERM and even in precision medicine. In this review, we aim to elaborate on recent achievements in a variety of CS/metal, CS/metalloid hybrid scaffolds, and discuss their applications in TERM. We also provide comprehensive insights into the formulation, surface modification, characterization, biocompatibility, and cytotoxicity of different types of CS-based OMSs.
通过将天然生物聚合物与无机材料（例如金属和类金属）相结合，在开发先进的混合生物结构方面取得了引人注目的成就，为生物活性有机金属支架（OMS）在组织工程和再生医学（TERM）中的应用铺平了道路。在各种生物聚合物中，壳聚糖（CS）由于其独特的特性（例如生物相容性、生物降解性、表面化学和功能化潜力）而被广泛用于开发生物活性 OMS。与无机元素结合使用时，CS 已被用于工程先进的仿生基质，以容纳嵌入的细胞和药物分子，并作为 TERM 中的支架。预计基于 CS 的 OMS 的使用将为 TERM 甚至精准医学提供新的实用潜力。在这篇综述中，我们旨在详细阐述各种 CS/金属、CS/类金属混合支架的最新成就，并讨论它们在 TERM 中的应用。我们还全面了解不同类型基于 CS 的 OMS 的配方、表面改性、表征、生物相容性和细胞毒性。
