Pavlov V A, Kotomtsev V V, Doronin A I, Sabadash E V
Ural Research Institute of Phthisiopulmonology, Ministry of Health of Russian Federation, Moscow, Russia.
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
Bull Exp Biol Med. 2016 Nov;162(1):63-65. doi: 10.1007/s10517-016-3546-4. Epub 2016 Nov 23.
Different sensitivity of guinea pigs and rats to Mycobacterium tuberculosis and membranotropic mutagenic xenobiotics is associated with differences in the metabolism of amino acid precursors of phospholipids. In turn, specific features of phospholipid metabolism are determined by differences in the level of sulfur-containing regulatory metabolites (methionine, taurine, and glutathione) in tissues. Taurine and methionine increase organism's resistance to Mycobacterium tuberculosis (typical of rats), glutathione and its constituent amino acids improve resistance to the mutagenic effects of xenobiotics (typical of guinea pigs). These metabolites can be used for strengthening of natural resistance to tuberculosis and mutagenic and carcinogenic xenobiotics.
豚鼠和大鼠对结核分枝杆菌以及膜亲和性诱变异生物的不同敏感性与磷脂氨基酸前体代谢的差异有关。反过来，磷脂代谢的特定特征由组织中含硫调节代谢物（蛋氨酸、牛磺酸和谷胱甘肽）水平的差异所决定。牛磺酸和蛋氨酸可增强机体对结核分枝杆菌的抵抗力（大鼠的典型特征），谷胱甘肽及其组成氨基酸可提高对异生物诱变作用的抵抗力（豚鼠的典型特征）。这些代谢物可用于增强对结核病以及诱变和致癌异生物的天然抵抗力。
