Pavlov V A
Probl Tuberk. 1998(2):30-2.
Mycobacterium tuberculosis (MT) (H37Rv strain, 0.1 mg) was subcutaneously administered to guinea-pigs and rats and 6 weeks later the content of free amino acids and oxidized and reduced glutahione were measured in the liver. The guinea-pigs were found to have higher levels of phosphoethanolamine (PEA), ethanolamine (EA), serine, and phenylalanine and lower concentrations of tyrosine. These changes are regarded as a sign of damaged cell membranes and impaired redox processes in the development of experimental tuberculosis (ET) in guinea-pigs. The compensatory adaptation in ET was increased levels of reduced glutathione and taurine. In intact rats, the hepatic level of taurine was 5 times higher and that of oxidized and reduced glutathione was twice less than in guinea-pigs. Rats did not develop ET, in them the level of taurine increased by twice more, that of PEA, EA, serine drastically dropped. Species-specific differences in the MT sensitivity of guinea-pigs and rats seem to be due to the differences in the levels of taurine.
将结核分枝杆菌（MT）（H37Rv菌株，0.1毫克）皮下注射给豚鼠和大鼠，6周后测量肝脏中游离氨基酸以及氧化型和还原型谷胱甘肽的含量。发现豚鼠的磷酸乙醇胺（PEA）、乙醇胺（EA）、丝氨酸和苯丙氨酸水平较高，酪氨酸浓度较低。这些变化被视为豚鼠实验性结核病（ET）发展过程中细胞膜受损和氧化还原过程受损的迹象。ET中的代偿性适应是还原型谷胱甘肽和牛磺酸水平升高。在未感染的大鼠中，肝脏中牛磺酸的水平比豚鼠高5倍，氧化型和还原型谷胱甘肽的水平比豚鼠低两倍。大鼠未发生ET，它们的牛磺酸水平增加了两倍多，PEA、EA、丝氨酸的水平急剧下降。豚鼠和大鼠对MT敏感性的种属特异性差异似乎是由于牛磺酸水平的差异。
