Pavlov V A, Sabadash E V, Fadina O V, Mironova A L
Probl Tuberk. 2002(11):40-4.
Harmful environmental agents [polycyclic aromatic hydrocarbons (PAH)] have been ascertained to greatly stimulate the biosynthesis of arginine and urea and reduce the amount of sulfur-containing metabolites in the liver of experimental animals by increasing the level of sulfur sulfate. Against this background, contamination with Mycobacteria tuberculosis (MBT) inhibits the activity of arginine and drastically decreases its amount by elevating the concentration of sulfur-containing metabolites. The supplementary administration of sodium glutamate to animals receiving PAH and MBT potentiates a decrease in nitrogen-rich metabolites and increases the level of sulfur-containing metabolites guinea pigs, tuberculosis resistance being on the rise. Under the influence of a combined action of PAH and MBT, the mutagenic effect of the former lowered in rats.
有害环境因子[多环芳烃（PAH）]已被确定会极大地刺激精氨酸和尿素的生物合成，并通过提高硫酸根水平来减少实验动物肝脏中含硫代谢物的量。在此背景下，结核分枝杆菌（MBT）感染会抑制精氨酸的活性，并通过提高含硫代谢物的浓度大幅降低其含量。给接受PAH和MBT的动物补充谷氨酸钠会增强富含氮的代谢物的减少，并提高含硫代谢物的水平，豚鼠的结核病抵抗力也会增强。在PAH和MBT的联合作用影响下，前者在大鼠中的诱变作用降低。
