Nomachi K, Mori M, Matsuda N
Department of Oral Surgery, School of Medicine, Gunma University, Maebashi, Japan.
Oral Surg Oral Med Oral Pathol. 1989 Jul;68(1):74-9. doi: 10.1016/0030-4220(89)90118-7.
A rare case of malignant acanthosis nigricans associated with lung cancer is presented. The case involved a 70-year-old man who had oral changes and various immunologic dysfunctions, including an increase in antinuclear antibodies. Oral lesions were characterized by papillary hyperplasia, formation of grooves, pigmentation of the upper lip and cheeks, and a loss of taste sensation. After the patient's lung cancer was treated with anticancer drugs, the histopathologic examination showed a marked improvement in oral lesions and significant normalization of immunologic abnormalities. The present case provides unique evidence that oral lesions associated with acanthosis nigricans have a significant correlation with lung cancer and high titers of antinuclear antibodies.
本文报告一例罕见的与肺癌相关的恶性黑棘皮病病例。该病例为一名70岁男性，出现口腔病变及多种免疫功能障碍，包括抗核抗体升高。口腔病变的特征为乳头样增生、沟纹形成、上唇和脸颊色素沉着以及味觉丧失。患者的肺癌经抗癌药物治疗后，组织病理学检查显示口腔病变明显改善，免疫异常显著恢复正常。本病例提供了独特的证据，表明与黑棘皮病相关的口腔病变与肺癌及高滴度抗核抗体具有显著相关性。
