Kubicka-Wołkowska Joanna, Dębska-Szmich Sylwia, Lisik-Habib Maja, Noweta Marcin, Potemski Piotr
Department of Chemotherapy, Medical University of Lodz, Paderewskiego 4, 93-509 Lodz, Poland.
BMC Urol. 2014 Nov 15;14:88. doi: 10.1186/1471-2490-14-88.
Acanthosis nigricans is characterized by hyperpigmentation and hyperkeratosis of the skin or mucous membranes. Its malignant form is associated with internal neoplasms, especially gastric adenocarcinoma (55-61%). Coexistence with prostate cancer is uncommon. In the paraneoplastic type of this dermatosis, the skin and mucous lesions are characteristically of more sudden onset and more severe than those in the benign form. The efficacy of various treatment strategies remains disappointing.
We here report a case of 66-year-old Caucasian patient with metastatic prostate cancer and a mild form of acanthosis nigricans that preceded the diagnosis of malignancy and resolved with chemotherapy in parallel with the prostate cancer. The dermatosis recurred when the prostate cancer progressed.
Concurrent acanthosis nigricans and prostate cancer is rare, and few such cases have been reported. Anti-tumor therapy occasionally results in regression of this dermatosis. Underlying malignant disease should be suspected in individuals with elderly-onset of acanthosis nigricans.
黑棘皮病的特征是皮肤或黏膜色素沉着过度和角化过度。其恶性形式与内脏肿瘤相关，尤其是胃腺癌（55 - 61%）。与前列腺癌共存并不常见。在这种皮肤病的副肿瘤类型中，皮肤和黏膜病变的特征是起病更突然，且比良性形式更严重。各种治疗策略的疗效仍然令人失望。
我们在此报告一例66岁的白种男性患者，患有转移性前列腺癌，在恶性肿瘤诊断之前出现轻度黑棘皮病，在前列腺癌化疗的同时，该皮肤病症状消失。当前列腺癌进展时，皮肤病复发。
黑棘皮病与前列腺癌同时存在的情况罕见，此类病例报道较少。抗肿瘤治疗偶尔会使这种皮肤病消退。对于老年起病的黑棘皮病患者，应怀疑存在潜在的恶性疾病。
