Cairo F, Rubino I, Rotundo R, Prato G P, Ficarra G
School of Dental Medicine, University of Florence, Italy.
J Periodontol. 2001 Sep;72(9):1271-5. doi: 10.1902/jop.2000.72.9.1271.
Acanthosis nigricans (AN) is a rare mucocutaneous condition that can involve the oral tissues. There are 2 clinical forms of AN: benign and malignant. Benign AN is related to systemic diseases such as diabetes and obesity or can be induced by drugs such as systemic corticosteroids, nicotinic acid, estrogens, insulin, and fusidic acid. Malignant AN appears in association with tumors such as lung, ovarian, breast, and gastric carcinoma.
A rare case of malignant AN that initially manifested in the oral cavity of a 73-year-old patient is reported.
A bladder and lung carcinoma were detected following the diagnosis of AN.
The diagnostic importance of oral AN is emphasized because, in our patient, its recognition led to the detection of 2 occult malignant tumors.
黑棘皮病（AN）是一种罕见的可累及口腔组织的黏膜皮肤疾病。AN有两种临床类型：良性和恶性。良性AN与糖尿病和肥胖等全身性疾病相关，或可由全身性皮质类固醇、烟酸、雌激素、胰岛素和夫西地酸等药物诱发。恶性AN与肺癌、卵巢癌、乳腺癌和胃癌等肿瘤相关。
报告一例罕见的恶性AN病例，最初表现为一名73岁患者的口腔病变。
AN诊断后检测出膀胱癌和肺癌。
强调口腔AN的诊断重要性，因为在我们的患者中，对其的识别导致发现了2个隐匿性恶性肿瘤。
