Krauss J S, Pantazis C G, Spurlock B O, Price L M, Neeley A E
Department of Pathology, Medical College of Georgia, Augusta 30912-3620.
Arch Pathol Lab Med. 1989 Aug;113(8):937-40.
In this report, we present a case of peripheral T-cell leukemia/lymphoma having mostly small- to medium-sized cells with abundant clear cytoplasmic vacuoles. The presentation at the time of diagnosis was one of leukemia/lymphoma. The phenotype of the leukemic cells of the peripheral blood was T1+, T11+, TQ1+, interleukin-2+, T3-, T4-, and T8-. The cells in the peripheral blood as well as those obtained from lymph node biopsy were strongly periodic acid-Schiff positive; the positivity was diastase sensitive. Electron microscopy confirmed the presence of glycogen in the cytoplasmic vacuoles. Serologic tests were negative for human T-cell lymphotropic virus type 1 antibody. The data presented in this article support the existence of a vacuolated variant of peripheral T-cell leukemia/lymphoma and further expand the morphological spectrum of T-cell lymphoproliferative disorders.
在本报告中，我们呈现了1例主要由小至中等大小细胞组成且伴有大量透明细胞质空泡的外周T细胞白血病/淋巴瘤病例。诊断时的表现为白血病/淋巴瘤。外周血白血病细胞的表型为T1+、T11+、TQ1+、白细胞介素-2+、T3-、T4-和T8-。外周血中的细胞以及从淋巴结活检获得的细胞均对过碘酸希夫反应呈强阳性；该阳性对淀粉酶敏感。电子显微镜证实细胞质空泡中存在糖原。血清学检测1型人类嗜T细胞病毒抗体为阴性。本文所呈现的数据支持外周T细胞白血病/淋巴瘤空泡化变异型的存在，并进一步扩展了T细胞淋巴增殖性疾病的形态学谱。
