McKay Marnee J, Baldwin Jennifer N, Ferreira Paulo, Simic Milena, Vanicek Natalie, Burns Joshua
From the Faculty of Health Sciences (M.J.M., J.N.B., P.F., M.S., J.B.), University of Sydney, New South Wales, Australia; Department of Sport, Health and Exercise Science (N.V.), University of Hull, UK; and Sydney Children's Hospitals Network (Randwick and Westmead) and Paediatric Gait Analysis Service of New South Wales (J.B.), Children's Hospital at Westmead, Sydney, Australia.
Neurology. 2017 Jan 3;88(1):36-43. doi: 10.1212/WNL.0000000000003466. Epub 2016 Nov 23.
To establish reference values for isometric strength of 12 muscle groups and flexibility of 13 joint movements in 1,000 children and adults and investigate the influence of demographic and anthropometric factors.
A standardized reliable protocol of hand-held and fixed dynamometry for isometric strength of ankle, knee, hip, elbow, and shoulder musculature as well as goniometry for flexibility of the ankle, knee, hip, elbow, shoulder, and cervical spine was performed in an observational study investigating 1,000 healthy male and female participants aged 3-101 years. Correlation and multiple regression analyses were performed to identify factors independently associated with strength and flexibility of children, adolescents, adults, and older adults.
Normative reference values of 25 strength and flexibility measures were generated. Strong linear correlations between age and strength were identified in the first 2 decades of life. Muscle strength significantly decreased with age in older adults. Regression modeling identified increasing height as the most significant predictor of strength in children, higher body mass in adolescents, and male sex in adults and older adults. Joint flexibility gradually decreased with age, with little sex difference. Waist circumference was a significant predictor of variability in joint flexibility in adolescents, adults, and older adults.
Reference values and associated age- and sex-stratified z scores generated from this study can be used to determine the presence and extent of impairments associated with neuromuscular and other neurologic disorders, monitor disease progression over time in natural history studies, and evaluate the effect of new treatments in clinical trials.
确定1000名儿童和成人12个肌肉群的等长肌力及13个关节活动度的柔韧性参考值,并研究人口统计学和人体测量学因素的影响。
在一项观察性研究中,对1000名年龄在3至101岁的健康男性和女性参与者,采用标准化的可靠方案,对手持式和固定式测力计测量踝关节、膝关节、髋关节、肘关节和肩部肌肉的等长肌力,以及用角度计测量踝关节、膝关节、髋关节、肘关节、肩部和颈椎的柔韧性。进行相关性和多元回归分析,以确定与儿童、青少年、成年人和老年人的肌力及柔韧性独立相关的因素。
得出了25项肌力和柔韧性测量的标准参考值。在生命的前20年中,年龄与肌力之间存在强线性相关性。老年人的肌肉力量随年龄显著下降。回归模型确定,身高增加是儿童肌力的最显著预测因素,体重增加是青少年肌力的最显著预测因素,而性别为男性是成年人和老年人肌力的最显著预测因素。关节柔韧性随年龄逐渐下降,性别差异不大。腰围是青少年、成年人和老年人关节柔韧性变异性差异的显著预测因素。
本研究得出的参考值以及相关的按年龄和性别分层的z评分,可用于确定与神经肌肉和其他神经系统疾病相关的损伤的存在和程度,在自然史研究中监测疾病随时间的进展,并在临床试验中评估新治疗方法的效果。