Scott Alex, Zwerver Johannes, Grewal Navi, de Sa Agnetha, Alktebi Thuraya, Granville David J, Hart David A
Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada Vancouver Coastal Health Research Institute, Centre for Hip Health and Mobility, Vancouver, British Columbia, Canada.
University of Groningen, University Medical Center Groningen, Center for Sports Medicine, Groningen, The Netherlands.
Br J Sports Med. 2015 Aug;49(15):984-8. doi: 10.1136/bjsports-2014-093989. Epub 2014 Dec 8.
Being overweight or obese is associated with an elevated risk of tendon pathology. However, for sportspeople the epidemiological data linking weight or adiposity on one hand, and risk of tendon pathology on the other, are less consistent. Indeed, the mechanistic links between diet, adiposity and tendon pathology remain largely unexamined. Recent studies have begun to examine the effects of dietary interventions on outcomes such as tendon biomechanics or pain. Oxidised low-density lipoprotein has been shown to (A) accumulate in the tendon tissues of mice that eat a fatty diet and (B) induce a pathological phenotype in human tendon cells. This paper addresses the current debate: is excessive body mass index (causing increased load and strain on tendon tissue) per se the underlying mechanism? Or do local or systemic influences of fat on tendons predispose to tendon pathology? This narrative review argues that excessive blood lipids may be an important avenue for clinical investigations.
超重或肥胖与肌腱病变风险升高相关。然而，对于运动员而言，一方面将体重或肥胖与另一方面的肌腱病变风险联系起来的流行病学数据并不那么一致。事实上，饮食、肥胖与肌腱病变之间的机制联系在很大程度上仍未得到研究。最近的研究已开始探讨饮食干预对诸如肌腱生物力学或疼痛等结果的影响。氧化型低密度脂蛋白已被证明：（A）在食用高脂饮食的小鼠的肌腱组织中积聚；（B）在人肌腱细胞中诱导病理表型。本文探讨了当前的争论：是过高的体重指数（导致肌腱组织上的负荷和应变增加）本身就是潜在机制吗？还是脂肪对肌腱的局部或全身影响易导致肌腱病变？这篇叙述性综述认为，血脂过高可能是临床研究的一个重要方向。
