Bilgin Cahit, Arbak Peri, Yavuz Ozlem, Balbay Ege Gulec, Balbay Oner, Annakkaya Ali Nihat
Dr. Cahit Bilgin, MD. Assistant Professor, Department of Chest Diseases, Sakarya University, Medical School, Sakarya, Turkey.
Prof. Dr. Peri Arbak, MD. Department of Chest Diseases, Duzce University, Medical School, Duzce, Turkey.
Pak J Med Sci. 2016 Sep-Oct;32(5):1169-1173. doi: 10.12669/pjms.325.10844.
There are few studies on the diesel exhaust particulates (DEP) / eosinophilic cationic protein (ECP) level relationship. This study aimed to detect ECP levels in a highly DE exposed group, named as toll collectors.
In a cross-sectional study, levels of serum ECP, rates of respiratory symptoms, mean levels of respiratory functions, smoking status, and variations in peak expiratory flow (PEF) during weekends and working days were compared for 68 toll collectors (TC) (range of age, 24-48 years) and 28 controls (range of age, 25-61 years). All subjects in the study group were men.
No significant difference was observed in terms of symptoms and smoking rates between the toll collectors and control group. The number of toll collectors [12/68 (17.7%) vs 1/28 (3.5%)] with diurnal PEF variability in the working period was higher than that of controls (p=0.058). Mean ECP level of toll collectors was higher than that of controls (32.8 vs 21.4 ng/L), but the difference was not significant. Mean ECP levels were higher in subjects experiencing diurnal PEF variability during work and off-work periods (34.9 vs 28.3 ng/L, p=0.410).
Serial PEF measurements combined with serum ECP measurements did not add a new tool to detect the sensitivity of workers dealing with DE. Much more diesel exhaust exposed workers should be included to search for cheap and available methods when evaluating airway.
关于柴油尾气颗粒物（DEP）/嗜酸性阳离子蛋白（ECP）水平关系的研究较少。本研究旨在检测一个高DEP暴露组（收费站工作人员）的ECP水平。
在一项横断面研究中，对68名收费站工作人员（TC）（年龄范围24 - 48岁）和28名对照组人员（年龄范围25 - 61岁）比较了血清ECP水平、呼吸道症状发生率、呼吸功能平均水平、吸烟状况以及周末和工作日期间呼气峰值流速（PEF）的变化。研究组所有受试者均为男性。
收费站工作人员与对照组在症状和吸烟率方面未观察到显著差异。工作期间有日间PEF变异性的收费站工作人员数量[12/68（17.7%）对1/28（3.5%）]高于对照组（p = 0.058）。收费站工作人员的平均ECP水平高于对照组（32.8对21.4 ng/L），但差异不显著。在工作和非工作期间经历日间PEF变异性的受试者中，平均ECP水平更高（34.9对28.3 ng/L，p = 0.410）。
连续PEF测量结合血清ECP测量并未为检测接触DEP的工人的敏感性增加新工具。在评估气道时，应纳入更多柴油尾气暴露工人以寻找廉价且可行的方法。
