Frank Stefan, Aguirre Aitor, Hescheler Juergen, Kurian Leo
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of CologneCologne, Germany; Institute for Neurophysiology, University of CologneCologne, Germany; Center for Molecular Medicine (CMMC), University of CologneCologne, Germany.
Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego La Jolla, CA, USA.
Front Cell Dev Biol. 2016 Nov 9;4:128. doi: 10.3389/fcell.2016.00128. eCollection 2016.
Our conception of the human genome, long focused on the 2% that codes for proteins, has profoundly changed since its first draft assembly in 2001. Since then, an unanticipatedly expansive functionality and convolution has been attributed to the majority of the genome that is transcribed in a cell-type/context-specific manner into transcripts with no apparent protein coding ability. While the majority of these transcripts, currently annotated as long non-coding RNAs (lncRNAs), are functionally uncharacterized, their prominent role in embryonic development and tissue homeostasis, especially in the context of the heart, is emerging. In this review, we summarize and discuss the latest advances in understanding the relevance of lncRNAs in (re)building the heart.
自2001年人类基因组草图首次组装以来，我们长期聚焦于编码蛋白质的2%基因组的观念已发生了深刻变化。从那时起，人们发现基因组的大部分以细胞类型/背景特异性方式转录为没有明显蛋白质编码能力的转录本，其功能超乎预期地广泛且复杂。虽然目前大多数这些转录本被注释为长链非编码RNA（lncRNA），其功能尚未明确，但它们在胚胎发育和组织稳态，尤其是在心脏方面的重要作用正在显现。在这篇综述中，我们总结并讨论了在理解lncRNA与心脏（再）构建相关性方面的最新进展。
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