Chernyshov V P, Slukvin I I
Pediatriia. 1989(6):20-4.
The secretory immune system was found to be different in neonates and their mothers. The differences manifested in the low content of IgA and high content of the free secretory component in the child's saliva and tears as well as in neonatal milk. In order to study the local immunity of neonates, use was made of neonatal milk as a research object. The system of the complement C3-component synthesis on the mucous membranes appeared mature even in the neonatal period. Based on a comparative analysis of the subpopulations of the immunocompetent cells of blood and milk of neonates and their mothers the conclusion is made about the activation in the neonatal period of the immune system of the mucous membranes associated with the low functional activity of the systemic immunity. The comparative analysis of the immunosuppressive properties of the breast and neonatal milk has demonstrated that the low suppressor activity of secretory factors of the neonates' mucous membranes may be one of the causes of the local immunity activation.
人们发现新生儿及其母亲的分泌免疫系统存在差异。这些差异表现为儿童唾液、眼泪以及初乳中IgA含量低，游离分泌成分含量高。为了研究新生儿的局部免疫，将初乳作为研究对象。即使在新生儿期，黏膜上补体C3成分的合成系统似乎也已成熟。基于对新生儿及其母亲血液和乳汁中免疫活性细胞亚群的比较分析，得出结论：与全身免疫功能低下相关的黏膜免疫系统在新生儿期被激活。对母乳和初乳免疫抑制特性的比较分析表明，新生儿黏膜分泌因子的低抑制活性可能是局部免疫激活的原因之一。
