Chernyshov V P, Slukvin I I, Galanina I K
Biull Eksp Biol Med. 1987 Sep;104(9):340-2.
To examine the local immunity of the newborn and maternal mammary glands the distribution of regulatory lymphocyte subsets, Ia-positive cells, free secretory component (Sc) and secretory IgA (SIgA) has been studied in maternal and neonatal milk. In the maternal milk there was a positive correlation between the relative number of Ia-positive cells and the level of SIgA, and a reverse correlation between the percentage of cytotoxic (suppressor) cells and free Sc level. No such correlations were observed on the neonatal milk. A high level of It-positive cells in the neonatal milk suggests a high functional activity of the local immunity in the mammary gland of the newborn. A high Sc level and a very low SIgA level were found in the neonatal milk. The relative immaturity and autonomy of the local immunity were observed in the neonatal mammary gland.
为研究新生儿和母体乳腺的局部免疫，对母体和新生儿乳汁中调节性淋巴细胞亚群、Ia阳性细胞、游离分泌成分（Sc）和分泌型IgA（SIgA）的分布进行了研究。在母体乳汁中，Ia阳性细胞的相对数量与SIgA水平呈正相关，而细胞毒性（抑制性）细胞百分比与游离Sc水平呈负相关。在新生儿乳汁中未观察到此类相关性。新生儿乳汁中高水平的It阳性细胞表明新生儿乳腺局部免疫的高功能活性。在新生儿乳汁中发现Sc水平高而SIgA水平极低。在新生儿乳腺中观察到局部免疫的相对不成熟和自主性。
