WONOEP评估：癫痫中的影像生物标志物

WONOEP appraisal: Imaging biomarkers in epilepsy.

作者信息

van Vliet Erwin A, Dedeurwaerdere Stefanie, Cole Andrew J, Friedman Alon, Koepp Matthias J, Potschka Heidrun, Immonen Riikka, Pitkänen Asla, Federico Paolo

机构信息

Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Department of Translational Neurosciences, University of Antwerp, Wilrijk, Belgium.

出版信息

Epilepsia. 2017 Mar;58(3):315-330. doi: 10.1111/epi.13621. Epub 2016 Nov 24.

DOI:10.1111/epi.13621

PMID:27883181

Abstract

Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy.

摘要

神经影像学提供了广泛的机会来获取有关神经元活动、脑炎症、血脑屏障改变以及癫痫发生过程中各种分子改变的信息，或用于预测药物反应性以及术后结果。在2015年由国际抗癫痫联盟（ILAE）神经生物学委员会组织的第十三届癫痫神经生物学研讨会（XIII WONOEP）期间，对成像生物标志物进行了研究。在此，我们展示了所讨论问题的扩展摘要，并概述了目前关于不同神经影像学方法在癫痫生物标志物潜力方面的知识现状。