Chen Mei X, Alexander Kenneth S, Baki Gabriella
Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Ave., Toledo, OH 43614, USA.
J Pharm (Cairo). 2016;2016:5754349. doi: 10.1155/2016/5754349. Epub 2016 Nov 3.
Skin infections occur commonly and often present therapeutic challenges to practitioners due to the growing concerns regarding multidrug-resistant bacterial, viral, and fungal strains. The antimicrobial properties of zinc sulfate and copper sulfate are well known and have been investigated for many years. However, the synergistic activity between these two metal ions as antimicrobial ingredients has not been evaluated in topical formulations. The aims of the present study were to (1) formulate topical creams and gels containing zinc and copper alone or in combination and (2) evaluate the antibacterial activity of these metal ions in the formulations. Formulation of the gels and creams was followed by evaluating their organoleptic characteristics, physicochemical properties, and antibacterial activity against and . Zinc sulfate and copper sulfate had a strong synergistic antibacterial activity in the creams and gels. The minimum effective concentration was found to be 3 w/w% for both active ingredients against the two tested microorganisms. This study evaluated and confirmed the synergistic antibacterial effect of copper sulfate and zinc sulfate in a cream and two gels.
皮肤感染很常见，由于对多重耐药细菌、病毒和真菌菌株的担忧日益增加，常常给从业者带来治疗挑战。硫酸锌和硫酸铜的抗菌特性是众所周知的，并且已经研究了很多年。然而，这两种金属离子作为抗菌成分之间的协同活性尚未在局部用制剂中进行评估。本研究的目的是：（1）制备单独或组合含有锌和铜的局部用乳膏和凝胶；（2）评估这些制剂中这些金属离子的抗菌活性。在制备凝胶和乳膏后，评估它们的感官特性、物理化学性质以及对[具体细菌名称1]和[具体细菌名称2]的抗菌活性。硫酸锌和硫酸铜在乳膏和凝胶中具有很强的协同抗菌活性。发现两种活性成分对两种受试微生物的最低有效浓度均为3 w/w%。本研究评估并证实了硫酸铜和硫酸锌在一种乳膏和两种凝胶中的协同抗菌作用。
