Mahajan B B, Dhawan Mohit, Singh Rajwinder
Department of Dermatology, Venereology and Leprology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.
Indian J Sex Transm Dis AIDS. 2013 Jan;34(1):32-4. doi: 10.4103/0253-7184.112867.
Herpes genitalis is one of the commonest sexually transmitted infections in the world caused by herpes simplex virus (HSV) 1 and 2. All herpes viruses show latency. Herpes genitalis caused by HSV-1 and HSV-2 is recurrent in 55 and 90% of case respectively.
To comparatively evaluate the therapeutic efficacy of topical zinc sulfate (ZnSO4) in varying concentrations in herpes genitalis.
Ninety patients clinically diagnosed as herpes genitalis and confirmed by Tzanck test were taken up for study and divided into 3 groups of 30 patients each which were applied topical ZnSO4 in concentrations of 1%, 2% and 4% respectively for 3 months. Ten patients of herpes genitalis were kept as control in whom only distilled water was applied. Patients were followed up for a total period of 6 months for any recurrences.
Ten patients of group 1 (1% ZnSO4) showed recurrence, 6 patients in group 2 (2% ZnSO4) and only one patient in group 3 (4% ZnSO4) showed recurrence. In the control group, 8 out of 10 patients showed recurrence. No serious side effects were seen in all 3 groups.
Topical ZnSO4 has been found to be an effective therapeutic modality not only for treatment but also for prolonging remissions in herpes genitalis. Topical 4% ZnSO4 has been found to be most efficacious out of the three concentrations, without any side effects.
生殖器疱疹是世界上最常见的性传播感染之一，由单纯疱疹病毒（HSV）1型和2型引起。所有疱疹病毒都具有潜伏性。由HSV-1和HSV-2引起的生殖器疱疹复发率分别为55%和90%。
比较评估不同浓度的局部硫酸锌（ZnSO4）治疗生殖器疱疹的疗效。
选取90例临床诊断为生殖器疱疹且经Tzanck试验确诊的患者进行研究，分为3组，每组30例，分别外用浓度为1%、2%和4%的ZnSO4，持续3个月。选取10例生殖器疱疹患者作为对照组，仅外用蒸馏水。对患者进行为期6个月的随访，观察有无复发情况。
第1组（1% ZnSO4）有10例患者复发，第2组（2% ZnSO4）有6例患者复发，第3组（4% ZnSO4）仅有1例患者复发。对照组10例患者中有8例复发。所有3组均未出现严重副作用。
已发现局部应用ZnSO4不仅是治疗生殖器疱疹的有效方法，而且还能延长缓解期。已发现3种浓度中4%的局部ZnSO4最有效，且无任何副作用。
