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[Preparation and pharmacologic activity of N-oxides of 4'-(benzotriazol-2-yl-phenylalkanoic and -phenoxyalkanoic acids].

作者信息

Boido A, Vazzana I, Sparatore F, Cappello B, Diurno V, Matera C, Marrazzo R, Russo S, Cenicola M L, Marmo E

机构信息

Istituto di Scienze Farmaceutiche, Università di Genova.

出版信息

Farmaco. 1989 Mar;44(3):257-77.

PMID:2789055
Abstract

A number of N-oxides of 4'-(benzotriazol-2-yl)-phenylalkanoic and -phenoxyalkanoic acids bearing various substituents on position 6 of benzotriazole together with 4'-(benzotriazol-2-yl) phenylacetic acid were prepared and subjected to a wide pharmacological screening. Several compounds exhibited significant antiinflammatory and diuretic activities, while one was endowed with antihypertensive activity.

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