Research on heterocyclic compounds. XII - Preparation and antiinflammatory activity of 2-methylimidazo [1,2-a]pyridine-3-carboxylic acids.

The synthesis of a series of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acids was accomplished by reacting some 2-aminopyridines with ethyl 2-chloroacetoacetate and then hydrolyzing the resulting ethyl carboxylates. Such new carboxylic acids were evaluated for antiinflammatory, analgesic, antipyretic, and ulcerogenic activities.