Kubíková-Kourilová A, Zahálková M
Neoplasma. 1978;25(4):439-44.
The changes in titres of isohemagglutinins anti-A and anti-B were followed up in 48 leukemic children during relapses and remissions. The levels of titres were compared 1. with levels in healthy children in the same age group, 2. in the different phases of disease in the same child. Compared with healthy children, a higher frequency of low isohemagglutinin levels was found in the phases of the exacerbation of malignancy, no changes were observed in remissions. In some children a quite evident fluctuation of isohemagglutinin titres in relation to the phases of the malignant disease was found. The depression of blood group isohemagglutinins in the phases of activation of the malignant process is considered as a partial defect in IgM, analogical to the so called normoglobulinemic defect of the antibodies.
对48例白血病患儿在复发期和缓解期的抗A和抗B同种血凝素效价变化进行了随访。将效价水平1. 与同年龄组健康儿童的水平进行比较，2. 与同一患儿疾病的不同阶段进行比较。与健康儿童相比，在恶性肿瘤加重阶段发现低同种血凝素水平的频率更高，缓解期未观察到变化。在一些患儿中，发现同种血凝素效价与恶性疾病阶段有相当明显的波动。恶性过程激活阶段血型同种血凝素的降低被认为是IgM的部分缺陷，类似于抗体的所谓正常球蛋白血症缺陷。
