Ohkawara S, Goto K, Mori S, Goto F, Saita N, Sagara T, Yoshinaga M
Department of Pathology, Kumamoto University Medical School, Japan.
Dermatologica. 1989;179 Suppl 1:84-90. doi: 10.1159/000248456.
Inflammation-induced immune enhancement was observed when an antigen was introduced during an early period of casein-induced inflammation. An immune potentiation factor was detected at the early inflammatory site of mice and rabbits. This immune potentiation factor of rabbits was identified as interleukin-1 (IL-1) in respect of either its biologic activities or its molecular structure. Expression of IL-1 mRNA was observed only in peritoneal exudate cells from the early inflammatory site in parallel with the generation of the immune potentiation activity. The inflammation-induced immune potentiation was assumed to be mediated by newly synthesized IL-1 at the early inflammatory site. By using immunocytochemical staining, it was definitely proved with respect to a single cell level that the polymorphonuclear leukocytes were the major cells in synthesizing IL-1 at the casein-induced inflammation in rabbits.
当在酪蛋白诱导的炎症早期引入抗原时，观察到炎症诱导的免疫增强。在小鼠和兔子的早期炎症部位检测到一种免疫增强因子。兔子的这种免疫增强因子，就其生物学活性或分子结构而言，被鉴定为白细胞介素-1（IL-1）。仅在早期炎症部位的腹膜渗出细胞中观察到IL-1 mRNA的表达，这与免疫增强活性的产生同时出现。炎症诱导的免疫增强被认为是由早期炎症部位新合成的IL-1介导的。通过免疫细胞化学染色，在单细胞水平上明确证明，多形核白细胞是兔子酪蛋白诱导炎症中合成IL-1的主要细胞。
