Rouwen A J, Wijermans P W, Boen-Tan T N, Stilma J S
Department of Ophthalmology, Free University Hospital, Amsterdam, The Netherlands.
Graefes Arch Clin Exp Ophthalmol. 1989;227(4):355-9. doi: 10.1007/BF02169412.
A case of therapy-resistant bilateral intermediate uveitis is presented. Vitreous biopsy and lumbar puncture resulted in the diagnosis of high-grade malignant non-Hodgkin's lymphoma (NHL). Because chemotherapy and radiotherapy continue to yield better results in the treatment of NHL and a cure can be reached in a large group of patients with high-grade malignant NHL, early diagnosis is very important. We therefore recommend early vitreous biopsy in persistent, bilateral, granulomatous intermediate uveitis, especially in older patients. Our patient achieved a complete remission (follow-up period at the time of writing, 18 months after the beginning of polychemotherapy and radiotherapy). The chemotherapy modalities are briefly discussed.
本文报告一例耐药性双侧中间葡萄膜炎病例。玻璃体活检和腰椎穿刺确诊为高级别恶性非霍奇金淋巴瘤（NHL）。由于化疗和放疗在NHL治疗中持续取得更好的效果，并且一大群高级别恶性NHL患者可以实现治愈，因此早期诊断非常重要。我们因此建议，对于持续性双侧肉芽肿性中间葡萄膜炎，尤其是老年患者，应尽早进行玻璃体活检。我们的患者实现了完全缓解（在撰写本文时的随访期，自开始多药化疗和放疗起18个月）。文中简要讨论了化疗方式。
