一项探讨肥胖的遗传和生活方式风险沟通影响的随机试验。
A randomized trial Examining The Impact Of Communicating Genetic And Lifestyle Risks For Obesity.
作者信息
Wang Catharine, Gordon Erynn S, Norkunas Tricia, Wawak Lisa, Liu Ching-Ti, Winter Michael, Kasper Rachel S, Christman Michael F, Green Robert C, Bowen Deborah J
机构信息
Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts, USA.
Coriell Institute for Medical Research, Camden, New Jersey, USA.
出版信息
Obesity (Silver Spring). 2016 Dec;24(12):2481-2490. doi: 10.1002/oby.21661.
OBJECTIVE
Genetic testing for obesity is available directly to consumers, yet little is understood about its behavioral impact and its added value to nongenetic risk communication efforts based on lifestyle factors.
METHODS
A randomized trial examined the short-term impact of providing personalized obesity risk information, using a 2 × 2 factorial design. Participants were recruited from the Coriell Personalized Medicine Collaborative (CPMC) and randomized to receive (1) no risk information (control), (2) genetic risk, (3) lifestyle risk, or (4) combined genetic/lifestyle risks. Baseline and 3-month follow-up survey data were collected. Analyses examined the impact of risk feedback on intentions to lose weight and self-reported weight.
RESULTS
A total of 696 participants completed the study. A significant interaction effect was observed for genetic and lifestyle information on intent to lose weight (P = 0.0150). Those who received genetic risk alone had greater intentions at follow-up, compared with controls (P = 0.0034). The impact of receiving elevated risk information on intentions varied by source and combination of risks presented. Non-elevated genetic risk did not lower intentions. No group differences were observed for self-reported weight.
CONCLUSIONS
Genetic risk information for obesity may add value to lifestyle risk information depending on the context in which it is presented.
目的
肥胖基因检测已可直接面向消费者，但对于其行为影响以及对基于生活方式因素的非基因风险沟通工作的附加价值，人们了解甚少。
方法
一项随机试验采用2×2析因设计，研究了提供个性化肥胖风险信息的短期影响。参与者从科里尔个性化医学协作组（CPMC）招募，并随机分为四组，分别接受：（1）无风险信息（对照组）；（2）基因风险信息；（3）生活方式风险信息；（4）基因/生活方式综合风险信息。收集了基线和3个月随访的调查数据。分析研究了风险反馈对减肥意愿和自我报告体重的影响。
结果
共有696名参与者完成了研究。在减肥意愿方面，基因和生活方式信息存在显著的交互作用（P = 0.0150）。与对照组相比，仅接受基因风险信息的参与者在随访时减肥意愿更强（P = 0.0034）。接受风险升高信息对意愿的影响因风险来源和呈现的风险组合而异。未升高的基因风险并未降低意愿。在自我报告体重方面未观察到组间差异。
结论
肥胖基因风险信息根据呈现的背景，可能会为生活方式风险信息增添价值。
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