Piuri Gabriele, Ferrazzi Enrico, Bulfoni Camilla, Mastricci Luciana, Di Martino Daniela, Speciani Attilio Francesco
a Inflammation Society , Church Hill , Orpington , BR6OHH , Kent, UK.
b Department of Woman, Mother, and Neonate, Unit of Obstetrics, Buzzi Children's Hospital , University of Milan School of Medicine , Milan , Italy EU.
J Matern Fetal Neonatal Med. 2017 Dec;30(23):2824-2830. doi: 10.1080/14767058.2016.1265929. Epub 2016 Dec 14.
The aim of this study was to assess longitudinal changes of bioimpedance analysis compared with anthropometric measurements in low-risk pregnant woman recruited in the first trimester and to observe possible differences in these indices in women who developed high-risk pregnancies.
Bioimpedance indices for the three trimesters of pregnancies were calculated separately for uneventful pregnancies delivered of newborns > the 10th centile. These findings were compared with anthropometric measurements. Data of women who developed hypertensive disorders of pregnancy (HDP) or delivered SGA newborns were calculated and compared.
Significantly longitudinal increases were observed in these pregnancies for total body water (TBW), free fat mass, fat mass, and extra-cellular water. These increases were paralleled body mass index (BMI), skinfolds, and waist measurements. The correlations between these two sets of findings were poor. Women who developed HDP with AGA fetuses showed significantly different bioimpedance from normal cases. TBW indices were highly significantly different since the first trimester. In pregnancies delivered of SGA newborns, these indices were opposite of the values observed in patients with HDP-AGA, TBW in these patients was significantly reduced compared with normal pregnancies.
The bioelectrical impedance is a fast, simple, noninvasive way to assess the TBW content in pregnancy. Our findings are in agreement with the hypothesis that bioimpedance might help to identify early in gestation patients at risk of developing different clinical phenotypes of hypertensive disease of pregnancy and SGA fetuses.
本研究旨在评估孕早期招募的低风险孕妇生物电阻抗分析与人体测量学指标的纵向变化，并观察高危妊娠女性这些指标的可能差异。
对分娩出生体重>第10百分位数新生儿的正常妊娠，分别计算孕期三个阶段的生物电阻抗指标。将这些结果与人体测量学指标进行比较。计算并比较发生妊娠高血压疾病（HDP）或分娩小于胎龄儿（SGA）新生儿的女性的数据。
在这些妊娠中观察到总体水（TBW）、去脂体重、脂肪量和细胞外液显著的纵向增加。这些增加与体重指数（BMI）、皮褶厚度和腰围测量结果平行。这两组结果之间的相关性较差。胎儿为适于胎龄儿（AGA）且发生HDP的女性，其生物电阻抗与正常情况显著不同。自孕早期起，TBW指标就有极显著差异。在分娩SGA新生儿的妊娠中，这些指标与HDP-AGA患者观察到的值相反，这些患者的TBW与正常妊娠相比显著降低。
生物电阻抗是评估孕期TBW含量的一种快速、简单、无创的方法。我们的研究结果与以下假设一致，即生物电阻抗可能有助于在妊娠早期识别有发生妊娠高血压疾病不同临床表型和SGA胎儿风险的患者。
