Yu Jiang, Zhang Yuyu, Du Yijun, Li Jun, Huang Baohua, Sun Wenbo, Cong Xiaoyan, Peng Jun, Ren Sufang, Gou Lihui, Shi Jianli, Chen Zhi, Chen Lei, Li Jianda, Yang Jie, Wu Jiaqiang, Wang Jinbao
Shandong Academy of Agricultural Sciences, Jinan, People's Republic of China; Shandong Key Lab of Animal Disease Control and Breeding, Jinan, People's Republic of China.
Shandong Academy of Agricultural Sciences, Jinan, People's Republic of China; Shandong Key Lab of Animal Disease Control and Breeding, Jinan, People's Republic of China; College of Veterinary Medicine, Shandong Agricultural University, Taian, People's Republic of China.
Res Vet Sci. 2016 Dec;109:166-168. doi: 10.1016/j.rvsc.2016.10.011. Epub 2016 Oct 24.
The use of BALB/c mouse as an alternative model to study Haemophilus parasuis (HPS) infections was evaluated, supplying the serotyping scheme by comparing the pathogenicity of different serovar HPS in pigs and mice challenge using statistical analysis. Results showed that the pathogenicity of different serovar HPS in mouse was consistent with in pigs, proving that this model is a viable alternative to pigs. It provides a convenient methodology for determining the virulence of HPS strains.
评估了使用BALB/c小鼠作为研究副猪嗜血杆菌（HPS）感染的替代模型，通过统计分析比较不同血清型HPS在猪和小鼠攻毒试验中的致病性，提供血清分型方案。结果表明，不同血清型HPS在小鼠中的致病性与在猪中一致，证明该模型是猪的可行替代模型。它为确定HPS菌株的毒力提供了一种便捷的方法。
