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面部重建手术的社会价值

Societal Value of Surgery for Facial Reanimation.

作者信息

Su Peiyi, Ishii Lisa E, Joseph Andrew, Nellis Jason, Dey Jacob, Bater Kristin, Byrne Patrick J, Boahene Kofi D O, Ishii Masaru

机构信息

Medical student, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

JAMA Facial Plast Surg. 2017 Mar 1;19(2):139-146. doi: 10.1001/jamafacial.2016.1419.

Abstract

IMPORTANCE

Patients with facial paralysis are perceived negatively by society in a number of domains. Society's perception of the health utility of varying degrees of facial paralysis and the value society places on reconstructive surgery for facial reanimation need to be quantified.

OBJECTIVE

To measure health state utility of varying degrees of facial paralysis, willingness to pay (WTP) for a repair, and the subsequent value of facial reanimation surgery as perceived by society.

DESIGN, SETTING, AND PARTICIPANTS: This prospective observational study conducted in an academic tertiary referral center evaluated a group of 348 casual observers who viewed images of faces with unilateral facial paralysis of 3 severity levels (low, medium, and high) categorized by House-Brackmann grade. Structural equation modeling was performed to understand associations among health utility metrics, WTP, and facial perception domains. Data were collected from July 16 to September 26, 2015.

MAIN OUTCOMES AND MEASURES

Observer-rated (1) quality of life (QOL) using established health utility metrics (standard gamble, time trade-off, and a visual analog scale) and (2) their WTP for surgical repair.

RESULTS

Among the 348 observers (248 women [71.3%]; 100 men [28.7%]; mean [SD] age, 29.3 [11.6] years), mixed-effects linear regression showed that WTP increased nonlinearly with increasing severity of paralysis. Participants were willing to pay $3487 (95% CI, $2362-$4961) to repair low-grade paralysis, $8571 (95% CI, $6401-$11 234) for medium-grade paralysis, and $20 431 (95% CI, $16 273-$25 317) for high-grade paralysis. The dominant factor affecting the participants' WTP was perceived QOL. Modeling showed that perceived QOL decreased with paralysis severity (regression coefficient, -0.004; 95% CI, -0.005 to -0.004; P < .001) and increased with attractiveness (regression coefficient, 0.002; 95% CI, 0.002 to 0.003; P < .001). Mean (SD) health utility scores calculated by the standard gamble metric for low- and high-grade paralysis were 0.98 (0.09) and 0.77 (0.25), respectively. Time trade-off and visual analog scale measures were highly correlated. We calculated mean (SD) WTP per quality-adjusted life-year, which ranged from $10 167 ($14 565) to $17 008 ($38 288) for low- to high-grade paralysis, respectively.

CONCLUSIONS AND RELEVANCE

Society perceives the repair of facial paralysis to be a high-value intervention. Societal WTP increases and perceived health state utility decreases with increasing House-Brackmann grade. This study demonstrates the usefulness of WTP as an objective measure to inform dimensions of disease severity and signal the value society places on proper facial function.

LEVEL OF EVIDENCE

NA.

摘要

重要性

面瘫患者在多个领域受到社会的负面看法。社会对不同程度面瘫的健康效用认知以及社会对面部重建手术用于面部复建的重视程度需要进行量化。

目的

测量不同程度面瘫的健康状态效用、对面部修复的支付意愿(WTP)以及社会所认为的面部复建手术的后续价值。

设计、场所和参与者:这项前瞻性观察性研究在一所学术性三级转诊中心进行,评估了348名普通观察者,他们观看了根据House - Brackmann分级分为3个严重程度等级(低、中、高)的单侧面瘫面部图像。进行结构方程模型分析以了解健康效用指标、WTP和面部认知领域之间的关联。数据收集于2015年7月16日至9月26日。

主要结局和测量指标

观察者使用既定的健康效用指标(标准博弈法、时间权衡法和视觉模拟量表)对(1)生活质量(QOL)进行评分,以及(2)他们对面部修复的WTP。

结果

在348名观察者中(248名女性[71.3%];100名男性[28.7%];平均[标准差]年龄为29.3[11.6]岁),混合效应线性回归显示,WTP随着面瘫严重程度的增加呈非线性增加。参与者愿意支付3487美元(95%置信区间,2362 - 4961美元)修复轻度面瘫,8571美元(95%置信区间,6401 - 11234美元)修复中度面瘫,20431美元(95%置信区间,16273 - 25317美元)修复重度面瘫。影响参与者WTP的主要因素是感知到的QOL。模型显示,感知到的QOL随着面瘫严重程度的增加而降低(回归系数,-0.004;95%置信区间,-0.005至-0.004;P <.001),并随着面部吸引力的增加而增加(回归系数,0.002;95%置信区间,0.002至0.003;P <.001)。通过标准博弈法计算的轻度和重度面瘫的平均(标准差)健康效用得分分别为0.98(0.09)和0.77((0.25))。时间权衡法和视觉模拟量表测量结果高度相关。我们计算了每个质量调整生命年的平均(标准差)WTP分别为10167美元(14565美元)至17008美元(38288美元)用于轻度至重度面瘫。

结论及意义

社会认为面瘫修复是一项高价值干预措施。随着House - Brackmann分级增加,社会WTP增加,而感知到的健康状态效用降低。本研究证明了WTP作为一种客观测量方法在告知疾病严重程度维度以及表明社会对面部正常功能重视程度方面的有用性。

证据水平

无。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a13/5469369/61c9563cf35a/nihms861105f1.jpg

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