Bilenko M V, Bulgakov V G, Morgunov A A
Kardiologiia. 1989 Jun;29(6):88-94.
Effects of oxidized yolk phospholipids (PL) on the coronary perfusion rate (CPR) and myocardial contractility were studied in the experiments with the isolated or isolated and 30-minute ischemia-induced heart of the rat or isolated myocardial strip of the frog. The oxidized PL were demonstrated to possess a more pronounced and steady negative inotropic effect than unoxidized PL, which was due to their direct dose-dependent damaging action on myocardial contractility. The oxidized PL also made the unrestored CPR worse in the early postischemic period, the concomitant administration of aspirin producing no effects and that of the antioxidant ionol making ischemic myocardial contractility better. The findings suggest that the circulating oxidized PL may contribute to the impairment of coronary tone and contractility of the intact or ischemic myocardium and the induction of endogenous processes of lipid peroxidation plays a role in showing these effects.
在大鼠离体或离体并经30分钟缺血处理的心脏以及青蛙离体心肌条的实验中，研究了氧化蛋黄磷脂（PL）对冠状动脉灌注率（CPR）和心肌收缩力的影响。结果表明，氧化PL比未氧化PL具有更显著且稳定的负性肌力作用，这是由于其对心肌收缩力具有直接的剂量依赖性损伤作用。氧化PL还使缺血后早期未恢复的CPR恶化，同时给予阿司匹林无作用，而给予抗氧化剂维生素E可改善缺血心肌的收缩力。这些发现提示，循环中的氧化PL可能导致完整或缺血心肌的冠状动脉张力和收缩力受损，内源性脂质过氧化过程在这些作用的表现中起作用。
