Brouckaert P G, Libert C, Everaerdt B, Takahashi N, Fiers W
Laboratory of Molecular Biology, State University of Gent, Belgium.
Lymphokine Res. 1989 Fall;8(3):269-74.
We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.
我们已经观察到，在小鼠模型中，人重组肿瘤坏死因子（hrTNF）与鼠重组肿瘤坏死因子（mrTNF）在体内抗肿瘤、诱导休克及诱导白细胞介素-6（IL-6）活性方面存在显著的种属特异性。我们还观察到，当协同因子共同给药时，这种种属特异性可以消除。我们现在提供的数据表明，致死剂量和非致死剂量内毒素诱导的IL-6和肿瘤坏死因子的情况有所不同。这些结果在一个双信号模型的背景下进行了讨论，该模型用于诱导主要的内毒素后现象，其中考虑了白细胞介素-1（IL-1）在肿瘤坏死因子体内作用中的参与。
