Coetzee A, Fourie P, Coetzee J, Badenhorst E, Rebel A, Bolliger C, Uebel R, Wium C, Lombard C
Department of Anesthesiology, University of Stellenbosch Medical School, Tygerberg, South Africa.
Anesth Analg. 1989 Oct;69(4):473-83.
The cardiovascular effects of propofol infusions, designed to maintain constant plasma concentrations, were examined in an open-chested pig model. Regional myocardial contractility was measured with the end-systolic pressure-length relationship (Ees) and left ventricular afterload quantified by the effective arterial elastance (Ea). The propofol plasma concentrations in this study varied between 0 and 7.73 (SEM 0.96) micrograms/mL. A significant correlation for the increasing propofol plasma concentration and a decrease in myocardial contractility (P = 0.0056) was demonstrated, and the Ea remained constant. This gave rise to a reduction in stroke volume (P = 0.002) and, combined with a decrease in the heart rate (P = 0.0001), led to a reduction in the cardiac output (P = 0.0001). When the propofol infusion was stopped, myocardial contractility did not recover in parallel with the decrease in plasma propofol concentration.
在开胸猪模型中研究了旨在维持恒定血浆浓度的丙泊酚输注的心血管效应。采用收缩末期压力-长度关系（Ees）测量局部心肌收缩力，通过有效动脉弹性（Ea）量化左心室后负荷。本研究中丙泊酚血浆浓度在0至7.73（标准误0.96）微克/毫升之间变化。结果表明，丙泊酚血浆浓度升高与心肌收缩力降低之间存在显著相关性（P = 0.0056），且Ea保持恒定。这导致每搏量减少（P = 0.002），并与心率降低（P = 0.0001）共同导致心输出量减少（P = 0.0001）。当停止丙泊酚输注时，心肌收缩力并未随着血浆丙泊酚浓度的降低而平行恢复。
