使用单光纤光学系统监测深部脑结构中的组织氧饱和度。
monitoring of tissue oxygen saturation in deep brain structures using a single fiber optical system.
作者信息
Yu Linhui, Wu Ying, Dunn Jeff F, Murari Kartikeya
机构信息
Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Canada.
Department of Radiology, Cumming School of Medicine, University of Calgary, Canada.
出版信息
Biomed Opt Express. 2016 Oct 21;7(11):4685-4694. doi: 10.1364/BOE.7.004685. eCollection 2016 Nov 1.
Abstract
We propose a single fiber optical system for monitoring tissue oxygen saturation () based on continuous-wave reflectance spectroscopy in the visible wavelengths. The system is designed for measurements in deep brain structures by stereotaxically implanting the 200 m-core fiber probe into the tissue of interest. Monte Carlo (MC) simulations were used to estimate the measurement tissue volume between 0.02-0.03 mm. Experiments in an optical phantom indicated the system had a root mean squared error (RMSE) of 4.21% compared with a commercial fluorescence-based tissue oxygen partial pressure measuring system. Finally, we used the system for continuously monitoring tissue from a highly-localized volume in anesthetized mice.
摘要
我们提出了一种基于可见波长连续波反射光谱的单光纤光学系统，用于监测组织氧饱和度（）。该系统设计用于通过立体定向将200微米芯光纤探头植入感兴趣的脑组织中进行测量。蒙特卡罗（MC）模拟用于估计0.02 - 0.03立方毫米之间的测量组织体积。在光学模型中的实验表明，与基于商业荧光的组织氧分压测量系统相比，该系统的均方根误差（RMSE）为4.21%。最后，我们使用该系统对麻醉小鼠高度局部化体积的组织进行连续监测。
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