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单纤维反射光谱的亚漫散射与吸收模型

Subdiffuse scattering and absorption model for single fiber reflectance spectroscopy.

作者信息

Post Anouk L, Faber Dirk J, Sterenborg Henricus J C M, van Leeuwen Ton G

机构信息

Amsterdam UMC, University of Amsterdam, Department of Biomedical Engineering and Physics, Cancer Center Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

The Netherlands Cancer Institute, Department of Surgery, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

出版信息

Biomed Opt Express. 2020 Oct 22;11(11):6620-6633. doi: 10.1364/BOE.402466. eCollection 2020 Nov 1.

Abstract

Single fiber reflectance (SFR) spectroscopy is a technique that is sensitive to small-scale changes in tissue. An additional benefit is that SFR measurements can be performed through endoscopes or biopsy needles. In SFR spectroscopy, a single fiber emits and collects light. Tissue optical properties can be extracted from SFR spectra and related to the disease state of tissue. However, the model currently used to extract optical properties was derived for tissues with modified Henyey-Greenstein phase functions only and is inadequate for other tissue phase functions. Here, we will present a model for SFR spectroscopy that provides accurate results for a large range of tissue phase functions, reduced scattering coefficients, and absorption coefficients. Our model predicts the reflectance with a median error of 5.6% compared to 19.3% for the currently used model. For two simulated tissue spectra, our model fit provides accurate results.

摘要

单纤维反射率(SFR)光谱学是一种对组织中的小规模变化敏感的技术。另一个好处是,可以通过内窥镜或活检针进行SFR测量。在SFR光谱学中,单根光纤发射并收集光。可以从SFR光谱中提取组织光学特性,并将其与组织的疾病状态相关联。然而,目前用于提取光学特性的模型仅针对具有修正的亨耶-格林斯坦相位函数的组织推导得出,不适用于其他组织相位函数。在此,我们将提出一种用于SFR光谱学的模型,该模型对于大范围的组织相位函数、约化散射系数和吸收系数都能提供准确的结果。与目前使用的模型相比,我们的模型预测反射率的中值误差为5.6%,而目前使用的模型为19.3%。对于两个模拟的组织光谱,我们的模型拟合提供了准确的结果。

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