Jacobsson L T, Axell T E, Hansen B U, Henricsson V J, Larsson A, Lieberkind K, Lilja B, Manthorpe R
Department of Medicine, Malmö General Hospital, Sweden.
J Autoimmun. 1989 Aug;2(4):521-7. doi: 10.1016/0896-8411(89)90185-6.
The prevalence of dry eyes or dry mouth, and of primary Sjögren's syndrome (primary SS) according to the Copenhagen criteria were established in 705 randomly selected subjects, aged 52-72 years who answered a simple questionnaire, and of whom 247 (35%) reported symptoms. A subgroup with symptoms (n = 77) and a matched asymptomatic control group (n = 32) were examined with the Schimer-1 test (S1t), tear film break-up time (BUT), van Bijsterveld score (vB), unstimulated whole sialometry (Sialo) and, in about 40% of them labial salivary gland (LSG) biopsy and salivary gland scintigraphy. Apart from four cases of keratoconjunctivitis sicca (KCS) among controls, cases of KCS (15), xerostomia (12), autoimmune sialoadenitis (6) and primary SS (6) were exclusively confined to the symtomatic group. The calculated frequencies (with 95% confidence intervals) for the whole population were 14.9 (7.3-22.6)% for KCS, 5.5(3.0-7.9)% for xerostomia and 2.7 (1.0-4.5)% for autoimmune sialoadenitis and primary SS. The serum levels of ANA and RF were similar in the two groups, though those of anti-SS-B/La antibodies were higher in the group with symptoms (P less than 0.01).
在705名年龄在52至72岁之间、回答了一份简单问卷的随机选取的受试者中，根据哥本哈根标准确定了干眼或口干以及原发性干燥综合征（原发性SS）的患病率，其中247人（35%）报告有症状。对有症状的亚组（n = 77）和匹配的无症状对照组（n = 32）进行了Schimer-1试验（S1t）、泪膜破裂时间（BUT）、范·比斯特费尔德评分（vB）、非刺激性全唾液流量测定（唾液流量）检查，并且约40%的受试者进行了唇唾液腺（LSG）活检和唾液腺闪烁扫描。除了对照组中有4例干燥性角结膜炎（KCS）外，KCS病例（15例）、口干症（12例）、自身免疫性涎腺炎（6例）和原发性SS（6例）仅局限于有症状组。整个人群中计算出的频率（95%置信区间）为KCS 14.9（7.3 - 22.6）%、口干症5.5（3.0 - 7.9）%、自身免疫性涎腺炎和原发性SS 2.7（1.0 - 4.5）%。两组的抗核抗体（ANA）和类风湿因子（RF）血清水平相似，不过有症状组的抗SS-B/La抗体水平更高（P小于0.01）。
