丹麦30至60岁人群中的干燥性角结膜炎和原发性干燥综合征
Keratoconjunctivitis sicca and primary Sjögren's syndrome in a Danish population aged 30-60 years.
作者信息
Bjerrum K B
机构信息
Department of Ophthalmology, Rigshospitalet and Eye Pathology Institute, University of Copenhagen, Denmark.
出版信息
Acta Ophthalmol Scand. 1997 Jun;75(3):281-6. doi: 10.1111/j.1600-0420.1997.tb00774.x.
PURPOSE
To investigate the presence of keratoconjunctivitis sicca and primary Sjögren's syndrome a sample of 504 persons aged 30-60 years from Copenhagen was studied.
METHODS
The presence of keratoconjunctivitis sicca and primary Sjögren's syndrome was estimated according to both the Copenhagen set of criteria and the preliminary European criteria.
RESULTS
Symptoms of dry eye and oral dryness were very common and with no significant correlation to age or sex. Keratoconjuncitivis sicca was most frequent in persons aged 50-59 years and was equally common in men and women. Primary Sjögren's syndrome could only be diagnosed in one person according to the Copenhagen criteria (cut-off the Schirmer-1 test < or = 5 mm/5 min), and in three persons according to the preliminary European criteria.
CONCLUSION
The frequency of keratoconjunctivitis sicca in persons aged 30-60 years in Copenhagen may be estimated to be 11% according to the Copenhagen criteria and 8% according to the preliminary European criteria. The frequency of primary Sjögren's syndrome in persons aged 30-60 years in Copenhagen may be estimated to be between 0.2% and 0.8% according to the Copenhagen criteria and between 0.6% and 2.1% according to the preliminary European criteria.
目的
为研究干燥性角结膜炎和原发性干燥综合征的患病情况，对来自哥本哈根的504名年龄在30至60岁之间的人员进行了抽样研究。
方法
根据哥本哈根标准集和欧洲初步标准评估干燥性角结膜炎和原发性干燥综合征的患病情况。
结果
干眼和口干症状非常常见，且与年龄或性别无显著相关性。干燥性角结膜炎在50至59岁人群中最为常见，在男性和女性中发病率相同。根据哥本哈根标准（Schirmer - 1试验临界值≤5毫米/5分钟），仅1人被诊断为原发性干燥综合征；根据欧洲初步标准，有3人被诊断为此病。
结论
根据哥本哈根标准，哥本哈根30至60岁人群中干燥性角结膜炎的发病率估计为11%；根据欧洲初步标准，这一发病率估计为8%。根据哥本哈根标准，哥本哈根30至60岁人群中原发性干燥综合征的发病率估计在0.2%至0.8%之间；根据欧洲初步标准，这一发病率估计在0.6%至2.1%之间。
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