Gupta Swati, Mishra K P, Ganju Lilly
Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
Arch Virol. 2017 Mar;162(3):611-623. doi: 10.1007/s00705-016-3166-3. Epub 2016 Nov 28.
Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress, Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). All these properties of andrographolide form the foundation for the use of this miraculous compound to restrain virus replication and virus-induced pathogenesis. The present article covers antiviral properties of andrographolide in variety of viral infections, with the hope of developing of a new highly potent antiviral drug with multiple effects.
穿心莲内酯，一种二萜类化合物，以其抗炎作用而闻名。它可以从多种穿心莲属植物中分离出来，穿心莲属植物通常被称为“苦草”。这种纯化的化合物已在各种应激条件下进行了抗炎作用测试，如缺血、发热、关节炎、肝毒性或神经毒性、癌症和氧化应激。除了抗炎作用外，穿心莲内酯还通过有效增强细胞毒性T细胞、自然杀伤（NK）细胞、吞噬作用和抗体依赖性细胞介导的细胞毒性（ADCC）表现出免疫调节作用。穿心莲内酯的所有这些特性构成了使用这种神奇化合物抑制病毒复制和病毒诱导发病机制的基础。本文涵盖了穿心莲内酯在多种病毒感染中的抗病毒特性，希望开发出一种具有多种作用的新型高效抗病毒药物。
