Inesi Giuseppe
California Pacific Medical Center Research Institute, San Francisco, California, USA.
IUBMB Life. 2017 Apr;69(4):211-217. doi: 10.1002/iub.1590. Epub 2016 Nov 28.
Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific proteins and toxic effects, elaborate systems of absorption, concentration buffering, delivery to specific protein sites and elimination, require a complex system including small carriers, chaperones and active transporters. The P-type copper ATPases ATP7A and ATP7B provide an important system for acquisition, active transport, distribution and elimination of copper. Relevance of copper metabolism to human diseases and therapy is already known. It is quite certain that further studies will reveal detailed and useful information on biochemical mechanisms and relevance to diseases. © 2016 IUBMB Life, 69(4):211-217, 2017.
铜在生物系统中具有广泛而重要的作用，它决定了许多金属蛋白和酶（如细胞色素氧化酶和超氧化物歧化酶）的构象和活性。此外，由于铜可能与非特异性蛋白质发生反应并产生毒性作用，因此需要一个复杂的系统来进行吸收、浓度缓冲、输送到特定蛋白质位点以及消除，这一系统包括小分子载体、伴侣蛋白和活性转运蛋白。P型铜ATP酶ATP7A和ATP7B为铜的获取、主动运输、分布和消除提供了一个重要系统。铜代谢与人类疾病及治疗的相关性已为人所知。可以肯定的是，进一步的研究将揭示有关生化机制及其与疾病相关性的详细且有用的信息。© 2016国际生物化学与分子生物学联盟生命科学，69(4):211 - 217, 2017。
