Li Te, Yu Chen
Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Int J Mol Sci. 2024 Dec 11;25(24):13279. doi: 10.3390/ijms252413279.
Renal fibrosis is a common final pathway underlying nearly almost all progressive kidney diseases. Metal ions are essential trace elements in organisms and are involved in important physiological activities. However, aberrations in intracellular metal ion metabolism may disrupt homeostasis, causing cell death and increasing susceptibility to various diseases. Accumulating evidence suggests a complex association between metal-dependent cell death and renal fibrosis. In this article, we provide a comprehensive overview of the specific molecular mechanisms of metal-dependent cell death and their crosstalk, up-to-date evidence supporting their role in renal fibrosis, therapeutic targeting strategies, and research needs, aiming to offer a rationale for future clinical treatment of renal fibrosis.
肾纤维化是几乎所有进行性肾脏疾病共同的最终途径。金属离子是生物体中的必需微量元素，参与重要的生理活动。然而，细胞内金属离子代谢异常可能会破坏体内平衡，导致细胞死亡，并增加对各种疾病的易感性。越来越多的证据表明，金属依赖性细胞死亡与肾纤维化之间存在复杂的关联。在本文中，我们全面概述了金属依赖性细胞死亡的具体分子机制及其相互作用、支持其在肾纤维化中作用的最新证据、治疗靶向策略以及研究需求，旨在为未来肾纤维化的临床治疗提供理论依据。
