Kim Jinhee, Lee Yunhwan, Kye Seunghee, Chung Yoon-Sok, Lee Okhee
Department of Preventive Medicine and Public Health, Ajou University School of Medicine, Suwon, Republic of Korea.
Institute on Aging, Ajou University Medical Center, Suwon, Republic of Korea.
J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):259-266. doi: 10.1002/jcsm.12154. Epub 2016 Oct 5.
Serum vitamin D levels have been reported to be associated with individual components of body composition. However, the relationship between serum vitamin D and combined indices of adverse body composition is largely unknown. This cross-sectional study examined the association between serum vitamin D and osteosarcopenic obesity in a nationally representative sample of middle-aged and older adults.
We analysed the Korea National Health and Nutrition Examination Surveys (IV and V) conducted in 2008-2010, consisting of 5908 (2485 men, 3423 women) aged ≥ 50 years. Serum vitamin D levels were determined by radioimmunoassay, and body composition was evaluated by dual-energy x-ray absorptiometry. The association between serum vitamin D levels and the number of abnormalities in body composition, including osteosarcopenic obesity, a low bone and muscle mass with concurrent high fat mass, was analysed by multinomial logistic regression adjusting for covariates.
In men, after controlling for covariates, higher vitamin D levels were associated with a significantly reduced likelihood of the number of phenotypes of adverse body composition (P for trend < 0.05). Those in the highest tertile group of serum vitamin D levels, compared with those in the lowest tertile, were less likely to have adverse body composition, numbering one (odds ratio [OR] = 0.67, 95% confidence interval [CI]: 0.49, 0.92), two (OR = 0.49, 95% CI: 0.33, 0.73), and three (osteosarcopenic obesity; OR = 0.42, 95% CI: 0.26, 0.67). In women, those in the highest tertile group of serum vitamin D levels, compared with those in the lowest tertile, were less likely to have osteosarcopenic obesity (OR = 0.55, 95% CI: 0.33, 0.93). Vitamin D deficiency (<20 ng/mL) in men was significantly associated with an increased likelihood of a higher number of adverse body composition, especially for osteosarcopenic obesity (OR = 2.08, 95% CI: 1.42, 3.03). Vitamin D deficient women, compared with those having normal levels of serum vitamin D, were also more likely to demonstrate osteosarcopenic obesity (OR = 1.99, 95% CI: 1.30, 3.05).
A high serum vitamin D level in mid- and late-life was associated with reduced odds of multiple adverse body composition, especially osteosarcopenic obesity, suggesting potential health benefits of maintaining adequate levels of vitamin D.
血清维生素D水平已被报道与身体成分的各个组成部分相关。然而，血清维生素D与不良身体成分综合指标之间的关系在很大程度上尚不清楚。这项横断面研究在一个具有全国代表性的中老年成年人样本中，考察了血清维生素D与骨质疏松性肥胖之间的关联。
我们分析了2008 - 2010年进行的韩国国家健康与营养检查调查（IV和V），该调查包括5908名年龄≥50岁的成年人（2485名男性，3423名女性）。血清维生素D水平通过放射免疫测定法测定，身体成分通过双能X线吸收法评估。通过多因素逻辑回归分析血清维生素D水平与身体成分异常数量之间的关联，包括骨质疏松性肥胖，即低骨量和肌肉量同时伴有高脂肪量，并对协变量进行了校正。
在男性中，在控制协变量后，较高的维生素D水平与不良身体成分表型数量显著降低的可能性相关（趋势P<0.05）。血清维生素D水平处于最高三分位数组的男性，与最低三分位数组的男性相比，出现不良身体成分的可能性较小，不良身体成分数量为1种（比值比[OR]=0.67，95%置信区间[CI]：0.49，0.92）、2种（OR=0.49，95%CI：0.33，0.73）以及3种（骨质疏松性肥胖；OR=0.42，95%CI：0.26，0.67）。在女性中，血清维生素D水平处于最高三分位数组的女性，与最低三分位数组的女性相比，患骨质疏松性肥胖的可能性较小（OR=0.55，95%CI：0.33，0.93）。男性维生素D缺乏（<20 ng/mL）与不良身体成分数量增加的可能性显著相关，尤其是骨质疏松性肥胖（OR=2.08，95%CI：1.42，3.03）。与血清维生素D水平正常的女性相比，维生素D缺乏的女性也更有可能表现出骨质疏松性肥胖（OR=1.99，95%CI：1.30，3.05）。
中老年时期血清维生素D水平较高与多种不良身体成分的几率降低相关，尤其是骨质疏松性肥胖，这表明维持充足的维生素D水平可能对健康有益。
