Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.
Nutrients. 2023 Jun 28;15(13):2933. doi: 10.3390/nu15132933.
Osteosarcopenic obesity (OSO) is a newly described coexistence of osteopenia/osteoporosis, sarcopenia, and obesity. We examined the association between pulmonary function, OSO, and its composition in adults aged ≥ 50 years. A total of 26,343 participants (8640 men; 17,703 women) were classified into four groups based on the number of abnormal body compositions (osteopenia/osteoporosis, sarcopenia, and obesity): 0 (control), 1+, 2+, and 3+ (OSO) abnormal body compositions. The values of forced volume vital capacity (FVC)%, forced expiratory volume in 1 s (FEV1%), and FEV1/FVC% were significantly decreased by increasing the number of adverse body compositions ( < 0.0001). Although the prevalence of restrictive spirometry pattern (RSP) was positively associated with a higher number of abnormal body composition parameters ( < 0.001), obstructive spirometry pattern (OSP) had no association with adverse body composition. In multivariate analyses, the adjusted odds ratios (ORs) for RSP compared to the control group were 1.36 in 1+, 1.47 in 2+, and 1.64 in 3+ abnormal body compositions ( for trend < 0.001). Multiple abnormal body composition, especially osteosarcopenic obesity, was independently associated with poor lung function showing RSP in older adults over 50 years. The coexistence of these abnormal body compositions may be a predisposing factor for pulmonary function deterioration.
骨质疏松-少肌型肥胖症（OSO）是一种新描述的骨质疏松/骨量减少、少肌症和肥胖同时存在的情况。我们研究了≥50 岁成年人的肺功能、OSO 及其组成之间的关系。共有 26343 名参与者（8640 名男性；17703 名女性）根据异常体成分（骨质疏松/骨量减少、少肌症和肥胖）的数量分为四组：0（对照组）、1+、2+和 3+（OSO）异常体成分。随着异常体成分数量的增加，用力肺活量（FVC）%、1 秒用力呼气量（FEV1%）和 FEV1/FVC%的值显著降低（<0.0001）。虽然限制性肺通气模式（RSP）的患病率与更高数量的异常体成分参数呈正相关（<0.001），但阻塞性通气模式（OSP）与异常体成分无关。在多变量分析中，与对照组相比，RSP 的调整后比值比（OR）在 1+时为 1.36，在 2+时为 1.47，在 3+时为 1.64（趋势<0.001）。多种异常体成分，尤其是骨质疏松-少肌型肥胖症，与 50 岁以上老年人的肺功能下降表现为 RSP 独立相关。这些异常体成分的共存可能是肺功能恶化的一个易感因素。
