托珠单抗治疗人疱疹病毒8型阳性/人类免疫缺陷病毒阴性多中心浆细胞型Castleman病
[Tocilizumab treatment of HHV8-positive/HIV-negative, multricentric plasma cell type Castleman's disease].
作者信息
Mûzes Györgyi, Csomor Judit, Sipos Ferenc
机构信息
II. Sz. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.
I. Sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary.
出版信息
Magy Onkol. 2016 Nov 29;60(4):328-332. Epub 2016 Apr 11.
PMID:27898752
Abstract
This is a case presentation of a HHV8-positive multicentric Castleman's disease (MCD) of plasma cell type. The patient failed to respond to combined immunosuppressive therapy and monoclonal anti-CD20 therapy. Interestingly, administration of anti-IL-6R antibody stabilized the disease and resulted in clearance of HHV8 from the involved lymph nodes.
摘要
这是一例浆细胞型人疱疹病毒8型（HHV8）阳性多中心Castleman病（MCD）的病例报告。该患者对联合免疫抑制治疗和单克隆抗CD20治疗均无反应。有趣的是，给予抗IL-6R抗体使病情稳定，并导致受累淋巴结中的HHV8清除。
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