A genomic study on distribution of () and alleles in Lak population of Iran.

Anthropological studies based on the highly polymorphic gene, (), provide useful information for bone marrow donor registry, forensic medicine, disease association studies, as well as infertility treatment, designing peptide vaccines against tumors, and infectious or autoimmune diseases. The aim of this study was to determine and allele frequencies in 100 unrelated Lak/lᴂk/individuals from Lorestan province of Iran. Finally, we compared the results with that previously described in Iranian population. Commercial HLA-Type kits from BAG (Lich, Germany) company were used for determination of the and allele frequencies in genomic DNA, based on polymerase chain reaction with sequence specific primer (PCR-SSP) assay. The differences between the populations in distribution of and alleles were estimated by chi-squared test with Yate's correction. The most frequent alleles were *24 (20%), *02 (18%), *03 (12%) and *11 (10%), and the most frequent alleles were *35 (24%), *51 (16%), *18 (6%) and *38 (6%) in Lak population. *66 (1%), *74(1%) and *48 (1%), *55(1%) were the least observed frequencies in Lak population. Our results based on and allele frequencies showed that Lak population possesses the previously reported general features of Iranians but still with unique.