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伊拉克、伊朗和第比利斯（格鲁吉亚高加索地区）库尔德人的人类白细胞抗原基因研究：关联性及医学意义

Genetic HLA Study of Kurds in Iraq, Iran and Tbilisi (Caucasus, Georgia): Relatedness and Medical Implications.

作者信息

Arnaiz-Villena Antonio, Palacio-Grüber Jose, Muñiz Ester, Campos Cristina, Alonso-Rubio Javier, Gomez-Casado Eduardo, Salih Shadallah Fareq, Martin-Villa Manuel, Al-Qadi Rawand

机构信息

Department of Immunology, University Complutense, School of Medicine, Madrid Regional Blood Center, Madrid, Spain.

Department of Inmunología Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Autopista A6, Hipódromo, Madrid, Spain.

出版信息

PLoS One. 2017 Jan 23;12(1):e0169929. doi: 10.1371/journal.pone.0169929. eCollection 2017.

DOI:10.1371/journal.pone.0169929
PMID:28114347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5256937/
Abstract

Kurds from Iraq (Dohuk and Erbil Area, North Iraq) have been analyzed for HLA genes. Their HLA genetic profile has been compared with that of other Kurd groups from Iran and Tbilisi (Georgia, Caucasus) and also Worldwide populations. A total of 7,746 HLA chromosomes have been used. Genetic distances, NJ dendrograms and correspondence analyses have been carried out. Haplotype HLA-B52-DRB115 is present in all three analyzed Kurd populations. HLA-A02-B51-DRB111 is present in Iraq and Georgia Kurds. Haplotypes common to Iran and Iraq Kurds are HLA DRB111-DQB103, HLA DRB103-DQB1*02 and others in a lower frequency. Our HLA study conclusions are that Kurds most probably belong to an ancient Mediterranean / Middle East / Caucasian genetic substratum and that present results and those previously obtained by us in Kurds may be useful for Medicine in future Kurd transplantation programs, HLA Epidemiology (HLA linked diseases) and Pharmacogenomics (HLA-associated drug side effects) and also for Anthropology. It is discussed that one of the most ancient Kurd ancestor groups is in Hurrians (2,000 years BC).

摘要

对来自伊拉克（伊拉克北部杜胡克和埃尔比勒地区）的库尔德人进行了HLA基因分析。他们的HLA基因图谱已与来自伊朗和第比利斯（格鲁吉亚，高加索地区）的其他库尔德人群体以及全球人群的图谱进行了比较。总共使用了7746条HLA染色体。进行了遗传距离分析、邻接树状图分析和对应分析。单倍型HLA - B52 - DRB115在所有三个被分析的库尔德人群体中均有出现。单倍型HLA - A02 - B51 - DRB111在伊拉克和格鲁吉亚的库尔德人中存在。伊朗和伊拉克库尔德人共有的单倍型有HLA DRB111 - DQB103、HLA DRB103 - DQB1*02以及其他频率较低的单倍型。我们关于HLA的研究结论是，库尔德人很可能属于一个古老的地中海/中东/高加索基因底层，并且目前的结果以及我们之前在库尔德人身上获得的结果可能对未来库尔德人的移植项目、HLA流行病学（与HLA相关的疾病）和药物基因组学（与HLA相关的药物副作用）以及人类学中的医学应用有用。讨论了最古老的库尔德祖先群体之一是胡里安人（公元前2000年）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/b54aa4d31768/pone.0169929.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/b150b3a494fd/pone.0169929.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/0821c8fd66e2/pone.0169929.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/b54aa4d31768/pone.0169929.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/b150b3a494fd/pone.0169929.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/0821c8fd66e2/pone.0169929.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ee/5256937/b54aa4d31768/pone.0169929.g003.jpg

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