Strigun L M, Chirkova E N, Grigor'eva G G, Gromova L A, Iakunina M A
Biull Eksp Biol Med. 1989 Jun;107(6):731-5.
In the series of experiments alpha-glycerophosphate dehydrogenase activity was daily determined at the same time by cytochemical method in the peripheral lymphocyte of normal rats and those with Walker carcinosarcoma. Using an original algorithm a hierarchy of biorhythms was singled out on a computer according to the individual changes in alpha-glycerophosphate dehydrogenase activity in each rat. It was shown that tumor development resulted in the reduction of the mean level of alpha-glycerophosphate dehydrogenase activity and considerable changes in diverse rhythms. Particular attention is paid to the phase changes, which can reveal changes in phase coordination of glycerophosphate shuttle cycle components.
在一系列实验中，每天同时采用细胞化学方法测定正常大鼠和患有沃克癌肉瘤大鼠外周淋巴细胞中的α-甘油磷酸脱氢酶活性。利用一种原始算法，根据每只大鼠α-甘油磷酸脱氢酶活性的个体变化，在计算机上筛选出生物节律层次结构。结果表明，肿瘤的发展导致α-甘油磷酸脱氢酶活性平均水平降低以及各种节律发生显著变化。特别关注相位变化，其可揭示甘油磷酸穿梭循环成分的相位协调变化。
