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[心脏移植过程中淋巴细胞脱氢酶活性变化的机制]

[Mechanism of changes in lymphocyte dehydrogenase activity during heart transplantation].

作者信息

Frolova M A, Gudkova R G, Bol'shukhina L A, Dukhova Z N, Fal'kvskiĭ G E

出版信息

Biull Eksp Biol Med. 1976;81(4):423-5.

PMID:776257
Abstract

A study was made of the activity of succinic dehydrogenase (SDH) and of the alpha-glycerophosphoric dehydrogenase (alpha-GPDH) in the peripheral blood lymphocytes and the transplant myocardium in the CBA mice in transplantation to them of the heart of newborn C57BL/6 mice into the pinna, subcutaneously. It appeared that the (see article) ratio in the myocardium and the lymphocytes of intact animals and also in the recipients of the isolinear transplant of the heart was greater than 1, but in allogenous transplantation this ratio became less than 1 on account of alpha-GPDH activation in the blood lymphocytes, which preceded the inversion in the transplant myocardium. It is supposed that the mentioned phenomenon was associated with the development of the immunological conflict.

摘要

对CBA小鼠耳廓皮下移植新生C57BL/6小鼠心脏后,其外周血淋巴细胞和移植心肌中的琥珀酸脱氢酶(SDH)及α-甘油磷酸脱氢酶(α-GPDH)活性进行了研究。结果发现,完整动物心肌和淋巴细胞以及心脏同基因移植受体中的(见文章)比值大于1,但在异基因移植中,由于血液淋巴细胞中α-GPDH激活先于移植心肌中的反转,该比值小于1。推测上述现象与免疫冲突的发生有关。

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Biull Eksp Biol Med. 1976;81(4):423-5.
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