Shanks N, Renton C, Zalcman S, Anisman H
Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada.
Pharmacol Biochem Behav. 1994 Mar;47(3):497-502. doi: 10.1016/0091-3057(94)90150-3.
Transferring CD-1 mice from grouped to individual housing and then maintaining them individually resulted in a decline in the peak IgM plaque-forming cell (PFC) response to sheep red blood cells (SRBCs). However, the immunosuppression was dependent on the amount of time mice were maintained individually. In particular, individual housing for 5-10 days prior to SRBC inoculation and for 4 days following inoculation resulted in a suppression of the splenic PFC response and serum antibody titers. Shorter periods of individual housing (4 days following inoculation) did not provoke the immunosuppression. Likewise, following more protracted individual housing (15-30 days prior to inoculation) the immunosuppression was not evident. Inasmuch as daily treatment with an anxiolytic, diazepam (1.0 mg/kg), antagonized the suppression induced by 5 days of individual housing, it was suggested that the change from group to individual housing and then maintenance of animals individually acted much like a stressor to induce the immunosuppression.
将CD - 1小鼠从群居饲养转移到单独饲养，然后一直单独饲养，会导致其对绵羊红细胞（SRBC）的IgM峰值空斑形成细胞（PFC）反应下降。然而，免疫抑制取决于小鼠单独饲养的时间长短。具体而言，在接种SRBC前单独饲养5 - 10天以及接种后饲养4天，会导致脾脏PFC反应和血清抗体滴度受到抑制。较短时间的单独饲养（接种后4天）不会引发免疫抑制。同样，在更长时间的单独饲养（接种前15 - 30天）后，免疫抑制也不明显。由于每日用抗焦虑药地西泮（1.0 mg/kg）进行治疗可对抗5天单独饲养所诱导的抑制作用，因此有人提出，从群居饲养转变为单独饲养然后一直单独饲养动物的这种变化，其作用类似于一种应激源，可诱导免疫抑制。
