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突尼斯心血管风险评估:将弗雷明汉风险评分应用于全国调查数据。

Assessment of cardiovascular risk in Tunisia: applying the Framingham risk score to national survey data.

作者信息

Saidi O, Malouche D, O'Flaherty M, Ben Mansour N, A Skhiri H, Ben Romdhane H, Bezdah L

机构信息

Faculty of Medicine of Tunis, Cardiovascular Epidemiology and Prevention Research Laboratory, Tunis, Tunisia.

National Institute of Public Health-Ministry of Health, Tunis, Tunisia.

出版信息

BMJ Open. 2016 Nov 30;6(11):e009195. doi: 10.1136/bmjopen-2015-009195.

Abstract

OBJECTIVE

This paper aims to assess the socioeconomic determinants of a high 10 year cardiovascular risk in Tunisia.

SETTING

We used a national population based cross sectional survey conducted in 2005 in Tunisia comprising 7780 subjects. We applied the non-laboratory version of the Framingham equation to estimate the 10 year cardiovascular risk.

PARTICIPANTS

8007 participants, aged 35-74 years, were included in the sample but effective exclusion of individuals with cardiovascular diseases and cancer resulted in 7780 subjects (3326 men and 4454 women) included in the analysis.

RESULTS

Mean age was 48.7 years. Women accounted for 50.5% of participants. According to the Framingham equation, 18.1% (17.25-18.9%) of the study population had a high risk (≥20% within 10 years). The gender difference was striking and statistically significant: 27.2% (25.7-28.7%) of men had a high risk, threefold higher than women (9.7%; 8.8-10.5%). A higher 10 year global cardiovascular risk was associated with social disadvantage in men and women; thus illiterate and divorced individuals, and adults without a professional activity had a significantly higher risk of developing a cardiovascular event in 10 years. Illiterate men were at higher risk than those with secondary and higher education (OR=7.01; 5.49 to 9.14). The risk in illiterate women was more elevated (OR=13.57; 7.58 to 24.31). Those living in an urban area had a higher risk (OR=1.45 (1.19 to 1.76) in men and OR=1.71 (1.35 to 2.18) in women).

CONCLUSIONS

The 10 year global cardiovascular risk in the Tunisian population is already substantially high, affecting almost a third of men and 1 in 10 women, and concentrated in those more socially disadvantaged.

摘要

目的

本文旨在评估突尼斯10年心血管疾病高风险的社会经济决定因素。

背景

我们采用了2005年在突尼斯进行的一项基于全国人口的横断面调查,共有7780名受试者。我们应用弗明汉姆方程的非实验室版本来估计10年心血管疾病风险。

参与者

样本纳入了8007名年龄在35 - 74岁之间的参与者,但对患有心血管疾病和癌症的个体进行有效排除后,分析中纳入了7780名受试者(3326名男性和4454名女性)。

结果

平均年龄为48.7岁。女性占参与者的50.5%。根据弗明汉姆方程,18.1%(17.25 - 18.9%)的研究人群具有高风险(10年内≥20%)。性别差异显著且具有统计学意义:27.2%(25.7 - 28.7%)的男性具有高风险,是女性(9.7%;8.8 - 10.5%)的三倍。男性和女性10年总体心血管疾病高风险均与社会劣势相关;因此,文盲和离异个体以及没有职业活动的成年人在10年内发生心血管事件的风险显著更高。文盲男性的风险高于接受过中等及以上教育的男性(OR = 7.01;5.49至9.14)。文盲女性的风险更高(OR = 13.57;7.58至24.31)。居住在城市地区的人风险更高(男性OR = 1.45(1.19至1.76),女性OR = 1.71(1.35至2.18))。

结论

突尼斯人群10年总体心血管疾病风险已经相当高,几乎影响到三分之一的男性和十分之一的女性,且集中在社会经济地位较低的人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0984/5168513/3bdded617716/bmjopen2015009195f01.jpg

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