奈托比敏和阿苯达唑在单峰骆驼（骆驼属单峰驼）中的比较药代动力学。

Comparative pharmacokinetics of netobimin and albendazole in the one-humped camel (Camelus dromedarius).

作者信息

Delatour P, Ouhsine A, Benoit E

出版信息

Br Vet J. 1989 Sep-Oct;145(5):478-82. doi: 10.1016/0007-1935(89)90058-4.

DOI:10.1016/0007-1935(89)90058-4

Abstract

Netobimin and albendazole were administered orally to camels (n = 5 + 5) at molecular equivalent dosages, 15.8 and 10.0 mg/kg body wt, respectively. The plasma profiles of the two main metabolites were investigated for 54 h by high performance liquid chromatography. The metabolism and the disposition of both anthelmintics in camels were similar to sheep rather than to cattle. These results indicate that netobimin and albendazole are likely to be excellent anthelmintics for camels.

摘要

将奈托比敏和阿苯达唑分别以分子等效剂量（分别为15.8和10.0毫克/千克体重）口服给予骆驼（n = 5 + 5）。通过高效液相色谱法对两种主要代谢物的血浆图谱进行了54小时的研究。两种驱虫药在骆驼体内的代谢和处置情况与绵羊相似，而与牛不同。这些结果表明，奈托比敏和阿苯达唑可能是骆驼的优良驱虫药。