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奈托比敏和阿苯达唑在单峰骆驼(骆驼属单峰驼)中的比较药代动力学。

Comparative pharmacokinetics of netobimin and albendazole in the one-humped camel (Camelus dromedarius).

作者信息

Delatour P, Ouhsine A, Benoit E

出版信息

Br Vet J. 1989 Sep-Oct;145(5):478-82. doi: 10.1016/0007-1935(89)90058-4.

DOI:10.1016/0007-1935(89)90058-4
PMID:2790441
Abstract

Netobimin and albendazole were administered orally to camels (n = 5 + 5) at molecular equivalent dosages, 15.8 and 10.0 mg/kg body wt, respectively. The plasma profiles of the two main metabolites were investigated for 54 h by high performance liquid chromatography. The metabolism and the disposition of both anthelmintics in camels were similar to sheep rather than to cattle. These results indicate that netobimin and albendazole are likely to be excellent anthelmintics for camels.

摘要

将奈托比敏和阿苯达唑分别以分子等效剂量(分别为15.8和10.0毫克/千克体重)口服给予骆驼(n = 5 + 5)。通过高效液相色谱法对两种主要代谢物的血浆图谱进行了54小时的研究。两种驱虫药在骆驼体内的代谢和处置情况与绵羊相似,而与牛不同。这些结果表明,奈托比敏和阿苯达唑可能是骆驼的优良驱虫药。

相似文献

1
Comparative pharmacokinetics of netobimin and albendazole in the one-humped camel (Camelus dromedarius).奈托比敏和阿苯达唑在单峰骆驼(骆驼属单峰驼)中的比较药代动力学。
Br Vet J. 1989 Sep-Oct;145(5):478-82. doi: 10.1016/0007-1935(89)90058-4.
2
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Plasma profiles of albendazole metabolites after administration of netobimin and albendazole in sheep: effects of parasitism and age.绵羊服用奈托比明和阿苯达唑后阿苯达唑代谢物的血浆曲线:寄生虫感染和年龄的影响
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Bioavailability of albendazole sulphoxide after netobimin administration in sheep: effects of fenbendazole coadministration.在绵羊中给予奈托比胺后阿苯达唑亚砜的生物利用度:芬苯达唑联合给药的影响。
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The pharmacokinetics of albendazole metabolites following administration of albendazole, albendazole sulfoxide and netobimin to one-month- and eight-month-old sheep.给1月龄和8月龄绵羊施用阿苯达唑、阿苯达唑亚砜和奈托比敏后阿苯达唑代谢物的药代动力学。
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Transplacental transport of netobimin metabolites in ewes.恩托比明代谢物在母羊体内的胎盘转运。
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Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: relationship with plasma disposition kinetics.给牛施用奈托比胺后阿苯达唑代谢物的胃肠道分布:与血浆处置动力学的关系
J Vet Pharmacol Ther. 1993 Mar;16(1):38-47. doi: 10.1111/j.1365-2885.1993.tb00287.x.

引用本文的文献

1
A survey of the literature (1995-1999) on the kinetics of drugs in camels (Camelus dromedarius).一项关于单峰骆驼(骆驼属单峰驼)药物动力学的文献综述(1995 - 1999年)。
Vet Res Commun. 2000 May;24(4):245-60. doi: 10.1023/a:1006498816669.
2
Transplacental transport of netobimin metabolites in ewes.恩托比明代谢物在母羊体内的胎盘转运。
Eur J Drug Metab Pharmacokinet. 1995 Jul-Sep;20(3):167-71. doi: 10.1007/BF03189665.