Minin A S, Belousova A V, Smolyuk L T, Ulitko M V, Uimin M A, Byzov I V
B. N. Eltsin Ural Federal University, Ekaterinburg, Russia.
M. N. Mikheev Institute of Metal Physics, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
Bull Exp Biol Med. 2016 Dec;162(2):248-251. doi: 10.1007/s10517-016-3587-8. Epub 2016 Dec 1.
Interactions of bimodal (fluorescent and magnetic) nanoparticles with HeLa cells were studied. The nanoparticles, characterized by high magnetic moment and relaxing capacity, exhibited fluorescence sufficient for their use as labels in confocal microscopy and flow cytometry. Penetration of these nanoparticles into the cell depended on their surface charge: positively charged nanoparticles of this structure penetrated inside, while negatively charged particles were not found in the cells.
研究了双峰（荧光和磁性）纳米颗粒与HeLa细胞的相互作用。这些纳米颗粒具有高磁矩和弛豫能力，其荧光足以用作共聚焦显微镜和流式细胞术中的标记物。这些纳米颗粒进入细胞的情况取决于它们的表面电荷：这种结构的带正电纳米颗粒能够进入细胞内部，而细胞中未发现带负电的颗粒。
