Melmed Kara R, Lyden Patrick D
Department of Neurology, Cedars-Sinai Medical Center , Los Angeles, California.
Ther Hypothermia Temp Manag. 2017 Sep;7(3):141-146. doi: 10.1089/ther.2016.0033. Epub 2016 Dec 1.
Therapeutic hypothermia (TH) is a potent neuroprotectant for experimental ischemic stroke, but studies of TH for intracerebral hemorrhage (ICH) are emerging. We systematically reviewed the experimental literature to assess TH efficacy for ICH. We found 18 suitable papers; quality scores were moderately good. Compared with normothermia, TH reduced measures of edema (mean effect size (95% CI) -1.6873 (-2.3640, -1.0106), p < 0.0001) or blood-brain barrier leakage (p < 0.0001) and improved behavioral outcomes (p < 0.0001). There was no evidence of publication bias. In this meta-analysis of available preclinical studies of ICH, TH is potently effective for reducing perihematomal edema and for improving behavioral outcomes.
治疗性低温（TH）是实验性缺血性中风的一种有效神经保护剂，但关于TH用于脑出血（ICH）的研究正在兴起。我们系统回顾了实验性文献，以评估TH对ICH的疗效。我们找到了18篇合适的论文；质量评分中等良好。与正常体温相比，TH降低了水肿指标（平均效应量（95%可信区间）-1.6873（-2.3640，-1.0106），p < 0.0001）或血脑屏障渗漏（p < 0.0001），并改善了行为结果（p < 0.0001）。没有证据表明存在发表偏倚。在这项对ICH现有临床前研究的荟萃分析中，TH对减轻血肿周围水肿和改善行为结果非常有效。
