Dumitrascu Oana M, Lamb Jessica, Lyden Patrick D
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA.
J Cereb Blood Flow Metab. 2016 Jul;36(7):1157-64. doi: 10.1177/0271678X16645112. Epub 2016 Apr 18.
Therapeutic hypothermia is the most potent neuroprotectant for experimental cerebral ischemia, illustrated in a 2007 meta-analysis published in this journal. To address recent therapeutic nihilism, we systematically reviewed recent experimental literature. Quality scoring showed considerable improvement in study design. Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic stroke re-emphasize that therapeutic hypothermia is potently effective, justifying further development in larger human clinical trials.
治疗性低温是实验性脑缺血最有效的神经保护剂，这在本杂志2007年发表的一项荟萃分析中得到了证实。为了应对近期出现的治疗虚无主义，我们系统地回顾了近期的实验文献。质量评分显示研究设计有了显著改进。在60篇包含216项比较的论文中，使用多种模型和物种的多种结果指标，与正常体温相比，治疗性低温具有保护作用，具有强大且具有统计学意义的标准化治疗效应量。在过去5年中，缺血性中风的临床前研究再次强调治疗性低温非常有效，这为在更大规模的人类临床试验中进一步开展研究提供了依据。
